After the death of his father Murat II, Mehmet II ascends to the Ottoman throne. After braving internal and external enemies, he decides to complete what he was destined to do: Conquer Constantinople.

Tirante the knight is as committed to fighting the Turks in Constantinople as he is to relieving Carmesina, the heiress to the Byzantine Empire, of her virginity.

In 1600, nobleman Orlando inherits his parents’ house, thanks to Queen Elizabeth I, who commands the young man to never change. After a disastrous affair with Russian princess Sasha, Orlando looks for solace in the arts before being appointed ambassador to Constantinople in 1700, where war is raging. One morning, Orlando is shocked to wake up as a woman and returns home, struggling as a female to retain her property as the centuries roll by.